Executive cognitive deficits in primary dystonia
Identifieur interne : 004093 ( Main/Exploration ); précédent : 004092; suivant : 004094Executive cognitive deficits in primary dystonia
Auteurs : Richard B. Scott [Royaume-Uni] ; Ralph Gregory [Royaume-Uni] ; Joanna Wilson [Royaume-Uni] ; Sarah Banks [Royaume-Uni] ; Anna Turner [Royaume-Uni] ; Simon Parkin [Royaume-Uni] ; Nir Giladi [Israël] ; Carol Joint [Royaume-Uni] ; Tipu Aziz [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 2003-05.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Adult, Brain (pathology), Cognition Disorders (diagnosis), Cognition Disorders (etiology), Cognition Disorders (physiopathology), Cognitive disorder, Disability Evaluation, Dystonia, Dystonia (complications), Dystonia (pathology), Dystonia (physiopathology), Exploration, Female, Human, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Neuropsychological test, Perceptual Disorders (complications), Perceptual Disorders (physiopathology), Primary, Psychometrics, Reaction Time, Severity of Illness Index, Visual Perception (physiology), executive deficits, neuropsychology, primary dystonia.
- MESH :
- complications : Dystonia, Perceptual Disorders.
- diagnosis : Cognition Disorders.
- etiology : Cognition Disorders.
- pathology : Brain, Dystonia.
- physiology : Visual Perception.
- physiopathology : Cognition Disorders, Dystonia, Perceptual Disorders.
- Adult, Disability Evaluation, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Reaction Time, Severity of Illness Index.
Abstract
Primary dystonia is a disorder of movement for which no consistent pathophysiology has been identified; in the absence of evidence to the contrary, it is assumed to be cognitively benign. We have studied a clinically heterogeneous group of 14 patients with primary dystonia on a battery of neuropsychological tests. Despite well‐preserved speed of information processing, language, spatial, memory and general intellectual skills relative to normal controls, we have identified a constellation of attentional–executive cognitive deficits on the Cambridge Neuropsychological Test Automated Battery (CANTAB). Specifically, patients demonstrated significant difficulties negotiating the extra‐dimensional set‐shifting phase of the IED task. The implications of these findings for the pathophysiology of primary dystonia are discussed. This is, to the best of our knowledge, the first report of a significant cognitive deficit in patients with primary dystonia. © 2003 Movement Disorder Society
Url:
DOI: 10.1002/mds.10399
Affiliations:
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><date type="published" when="2003-05">2003-05</date><biblScope unit="vol">18</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="539">539</biblScope><biblScope unit="page" to="550">550</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">F425E8BCF3D55429FB7DD7EAEEECA2B769ACEEBF</idno><idno type="DOI">10.1002/mds.10399</idno><idno type="ArticleID">MDS10399</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Brain (pathology)</term><term>Cognition Disorders (diagnosis)</term><term>Cognition Disorders (etiology)</term><term>Cognition Disorders (physiopathology)</term><term>Cognitive disorder</term><term>Disability Evaluation</term><term>Dystonia</term><term>Dystonia (complications)</term><term>Dystonia (pathology)</term><term>Dystonia (physiopathology)</term><term>Exploration</term><term>Female</term><term>Human</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Neuropsychological test</term><term>Perceptual Disorders (complications)</term><term>Perceptual Disorders (physiopathology)</term><term>Primary</term><term>Psychometrics</term><term>Reaction Time</term><term>Severity of Illness Index</term><term>Visual Perception (physiology)</term><term>executive deficits</term><term>neuropsychology</term><term>primary dystonia</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Dystonia</term><term>Perceptual Disorders</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Cognition Disorders</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cognition Disorders</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term><term>Dystonia</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Visual Perception</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Cognition Disorders</term><term>Dystonia</term><term>Perceptual Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Disability Evaluation</term><term>Female</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Reaction Time</term><term>Severity of Illness Index</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Dystonie</term><term>Exploration</term><term>Homme</term><term>Primaire</term><term>Psychométrie</term><term>Test neuropsychologique</term><term>Trouble cognition</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Primary dystonia is a disorder of movement for which no consistent pathophysiology has been identified; in the absence of evidence to the contrary, it is assumed to be cognitively benign. We have studied a clinically heterogeneous group of 14 patients with primary dystonia on a battery of neuropsychological tests. Despite well‐preserved speed of information processing, language, spatial, memory and general intellectual skills relative to normal controls, we have identified a constellation of attentional–executive cognitive deficits on the Cambridge Neuropsychological Test Automated Battery (CANTAB). Specifically, patients demonstrated significant difficulties negotiating the extra‐dimensional set‐shifting phase of the IED task. The implications of these findings for the pathophysiology of primary dystonia are discussed. This is, to the best of our knowledge, the first report of a significant cognitive deficit in patients with primary dystonia. © 2003 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Israël</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Oxfordshire</li></region><settlement><li>Oxford</li></settlement></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Scott, Richard B" sort="Scott, Richard B" uniqKey="Scott R" first="Richard B." last="Scott">Richard B. Scott</name></region><name sortKey="Aziz, Tipu" sort="Aziz, Tipu" uniqKey="Aziz T" first="Tipu" last="Aziz">Tipu Aziz</name><name sortKey="Banks, Sarah" sort="Banks, Sarah" uniqKey="Banks S" first="Sarah" last="Banks">Sarah Banks</name><name sortKey="Gregory, Ralph" sort="Gregory, Ralph" uniqKey="Gregory R" first="Ralph" last="Gregory">Ralph Gregory</name><name sortKey="Joint, Carol" sort="Joint, Carol" uniqKey="Joint C" first="Carol" last="Joint">Carol Joint</name><name sortKey="Parkin, Simon" sort="Parkin, Simon" uniqKey="Parkin S" first="Simon" last="Parkin">Simon Parkin</name><name sortKey="Scott, Richard B" sort="Scott, Richard B" uniqKey="Scott R" first="Richard B." last="Scott">Richard B. Scott</name><name sortKey="Turner, Anna" sort="Turner, Anna" uniqKey="Turner A" first="Anna" last="Turner">Anna Turner</name><name sortKey="Turner, Anna" sort="Turner, Anna" uniqKey="Turner A" first="Anna" last="Turner">Anna Turner</name><name sortKey="Wilson, Joanna" sort="Wilson, Joanna" uniqKey="Wilson J" first="Joanna" last="Wilson">Joanna Wilson</name></country><country name="Israël"><noRegion><name sortKey="Giladi, Nir" sort="Giladi, Nir" uniqKey="Giladi N" first="Nir" last="Giladi">Nir Giladi</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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